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Bees use propolis, or “bee glue,” as a sealant. Historically, humans have used it topically or as an oral supplement. However, it may not be suitable for everyone.

This article will look at what propolis is, what the research says about its potential benefits, and how to use it.

What is propolis?

Propolis is a resinous, waxy substance that bees create by mixing their saliva with beeswax, along with compounds from various plants and trees. Bees use it to seal gaps in the hive to keep out intruders. Propolis also has antimicrobial properties and may protect bees from pathogens.

The same 2019 review suggests that it may have the following properties:

antibacterial

antifungal

antiviral

antiprotozoal, which means that it works against parasitic illnesses, such as giardiasis

anti-inflammatory

antioxidant

Some of the substances present in propolis may also have anticancer properties.

However, although laboratory and animal studies into the properties of propolis and its components are promising, few high quality studies have proven its effectiveness as a treatment for specific conditions in humans.

Potential uses

Modern research suggests that propolis may be useful for:

minor wounds

oral hygiene

inflammation

cold sores

The following sections will look at some of this research in more detail.

Wound healing

One 2015 reviewTrusted Source suggests that propolis may aid wound healing. An animal study in rats with diabetes showed that propolis helped the skin grow new cells in order to repair itself.

Because people with diabetes can experience slow wound healing, this suggests that propolis could be beneficial for helping the skin heal more quickly. As propolis also kills some types of bacteria, it may also help prevent infection.

Oral health

According to the same 2015 reviewTrusted Source, propolis also appears to prevent the formation of calcium phosphate, which is the main component of dental plaque.

Animal studiesTrusted Source have tested propolis as an anti-inflammatory agent in rats and mice with arthritis. In both studies, the propolis inhibited swelling and appeared to have an impact on how the inflammation developed.

Scientists believe that propolis may regulate inflammatory substances in the body, such as prostaglandins.

Herpes

A systematic review in the journal Complementary Therapies in Medicine suggests that propolis may work as an alternative treatment for genital or oral herpes.

Herpes is caused by the herpes simplex virus (HSV). HSV-1 typically causes oral herpes, which can result in cold sores. HSV-2 is sexually transmitted, and it causes an infection that can result in painful blisters on the genitals.

In the review, researchers analyzed several trials into honey and propolis, comparing their effects with those of acyclovir, which is a common HSV medication. In 4 out of 6 trials, propolis was more effective than acyclovir for treating HSV skin lesions — particularly cold sores.

However, the researchers did not include a large number of trials in this review.

Insufficient evidence

Although people have used propolis for many health conditions in the past, there is not strong scientific evidence to support all of them.

The following sections will look at some of these health conditions in more detail.

Diabetes

According to the 2015 reviewTrusted Source, one older study in rats found that propolis was associated with lower blood sugar levels. However, this is not enough evidence to show that propolis can help with managing diabetes in humans.

Cancer

Laboratory studiesTrusted Source suggest that the compounds in propolis may inhibit cancer cell growth or induce cell death in cancer cells.

Some in vivo tests have shown that flavonoids from propolis can inhibit the development of oral cancer, lung cancer, skin cancer, breast cancer, and more.

However, much of the research in this field has involved isolated cells or animal models.

COVID-19

One 2020 study in the journal Phytotherapy ResearchTrusted Source argues that propolis’s antiviral properties may mean that it works against SARS-CoV-2. This is the coronavirus that causes COVID-19.

Previous laboratory studies have shown that propolis exhibits antiviral activity against other types of virus, including:

rhinoviruses

influenza (flu)

respiratory syncytial virus

Propolis also appears to help stimulate the immune system. For these reasons, the researchers suggest that propolis may help with preventing SARS-CoV-2 infection.

However, while clinical trials on propolis’s ability to prevent COVID-19 are underway, there is currently no evidence to suggest that it is effective for this purpose.

Allergies

One study in the journal Oxidative Medicine and Cellular LongevityTrusted Source notes that propolis contains compounds that may have an anti-allergy effect in the body.

Some people may feel a benefit from using propolis for this purpose. However, there is not much scientific evidence to prove that propolis can help reduce allergy symptoms.

Safety

Propolis appears to be safeTrusted Source for humans to use, at reasonable doses, both on the skin and internally. Reports of allergic reactions are rare, and there are no recorded cases of toxicity.